Document Detail

Immunofluorescent identification of fibronectin and fibrinogen/fibrin in experimental myocardial infarction.
MedLine Citation:
PMID:  1696997     Owner:  NLM     Status:  MEDLINE    
Distribution of fibrinogen/fibrin and fibronectin in regions of experimental myocardial infarction were studied by the immunofluorescence technique. Distinct from normal myocardium 3 and 12 to 24 h after coronary artery ligation infiltration of necrotized cardiomyocytes by fibrinogen/fibrin and plasma fibronectin was detected. Fibrinogen/fibrin and plasma fibronectin constitute "primary matrix" of granulation tissue. On the third day after experimental infarction, synthesis of cellular fibronectin begins. Its content in the extracellular matrix (ECM of granulation tissue significantly increases on days 7 to 15. The amount of fibronectin in the ECM of developing scar tissue dramatically decreases 30 days after infarction, Fibrinogen/fibrin was continually identified in granulation tissue in zones of myocardial infarction. However, its amount in the ECM of developing scar tissue gradually decreased.
B V Shekhonin; S B Guriev; S B Irgashev; V E Koteliansky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  22     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  533-41     Citation Subset:  IM    
Institute of Experimental Cardiology, USSR Cardiology Research Center, Moscow.
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MeSH Terms
Antibodies / diagnostic use,  immunology
Antibodies, Monoclonal / diagnostic use,  immunology
Arteries / surgery
Chronic Disease
Coronary Aneurysm / etiology,  pathology
Coronary Vessels / surgery
Epitopes / immunology
Fibrin / immunology,  metabolism*
Fibrinogen / immunology,  metabolism*
Fibronectins / immunology,  metabolism*
Fluorescent Antibody Technique
Granulation Tissue / pathology
Myocardial Infarction / complications,  metabolism*,  pathology
Myocardium / metabolism,  pathology
Rats, Inbred Strains
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Monoclonal; 0/Epitopes; 0/Fibronectins; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

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