Document Detail

Immunofluorescence of synovial membrane multifactorial analysis of the results.
MedLine Citation:
PMID:  793644     Owner:  NLM     Status:  MEDLINE    
Synovial membrane taken by needle biopsy from the knee joint of 61 patients with various rheumatic diseases were studied using immunofluorescence methods. Staining techniques and their controls were detailed. Classical statistical tests and principal components multifactorial analysis of the data emphasized some differences between the pathological groups. Connective tissue diseases seemed to be characterized by plasma cells fluorescence and mixed immunoglobulins and complement deposits. These were mostly localized to extracellular spaces in sero-positive rheumatoid arthritis and to blood vessels in sero-negative rheumatoid arthritis and systemic lupus erythematosus. On the contrary, isolated immunoglobulins without complement were mostly found in the other inflammatory arthritis, while negative results were obtained in non inflammatory arthropathy. Immunoglobulin classes did not seem to have any diagnostic value. On the contrary, rheumatoid factor was specific for rheumatoid arthritis, whatever the serological pattern was, and it was particularly frequent in patients suffering from rheumatoid arthritis associated with a Sj5AOGREN SYNDROME. A strict relationship between classical histological findings and immunofluorescence results was not always found; so, immunological methods can be aquivocal.
D Piatier; A Le Gô; H Brouilhet; M Rabaud; B Amor; F Delbarre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine / [publiée pour l'A.A.I.C.I.G.]     Volume:  24     ISSN:  0300-0893     ISO Abbreviation:  Biomedicine     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0361342     Medline TA:  Biomedicine     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  359-66     Citation Subset:  IM    
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MeSH Terms
Arthritis / immunology*
Arthritis, Rheumatoid / immunology
Blood Vessels / immunology
Collagen Diseases / immunology*
Complement System Proteins / analysis
Extracellular Space / immunology
Factor Analysis, Statistical
Fluorescent Antibody Technique
Immunoglobulins / analysis
Joint Diseases / diagnosis,  immunology
Knee Joint / immunology
Lupus Erythematosus, Systemic / immunology
Plasma Cells / immunology
Rheumatoid Factor / analysis
Synovial Membrane / immunology*,  pathology
Reg. No./Substance:
0/Immunoglobulins; 9007-36-7/Complement System Proteins; 9009-79-4/Rheumatoid Factor

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