Document Detail


Immunofluorescence studies indicate that the basic trypsin-kallikrein-inhibitor of bovine organs (Trasylol) originates from mast cells.
MedLine Citation:
PMID:  374218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using the indirect immunofluorescence technique, the basic kallikrein-trypsin inhibitor of bovine organs, Trasylol, could be localized in tissue mast cells of bovine lung, liver, pancreas and parotid gland. Identification of cells exhibiting specific fluorescence as tissue mast cells was achieved by combined light and electron microscopic diagnosis of bovine liver tissue sections. The presence of Trasylol in mast cells explains the widespread distribution of this inhibitor in functionally totally different organs or tissues of the bovine organism, as determined earlier by biochemical means. Identification of Trasylol as a mast cell constituent will facilitate the search for the biological function of this inhibitory protein in connection with a unique and highly specialized cell population.
Authors:
H Fritz; J Kruck; I Rüsse; H G Liebich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hoppe-Seyler's Zeitschrift für physiologische Chemie     Volume:  360     ISSN:  0018-4888     ISO Abbreviation:  Hoppe-Seyler's Z. Physiol. Chem.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985060R     Medline TA:  Hoppe Seylers Z Physiol Chem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  437-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aprotinin / analysis*
Cattle
Fluorescent Antibody Technique
Liver / analysis
Lung / analysis
Mast Cells / analysis*
Pancreas / analysis
Parotid Gland / analysis
Chemical
Reg. No./Substance:
9087-70-1/Aprotinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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