Document Detail

Immunofluorescence detection of cadherins in mouse tooth germs during root development.
MedLine Citation:
PMID:  10391499     Owner:  NLM     Status:  MEDLINE    
The distribution of two cell-adhesion molecules, E- and P-cadherin, was studied in relation to morphological changes in Hertwig's epithelial root sheath Before root dentinogenesis had started, the root sheath expressed both cadherins. As dentinogenesis proceeded, the sheath fragmented and lost P-cadherin rapidly and E-cadherin slowly, whereas the intact sheath at the apical end continued to express both. These results suggest that the two cadherins play a part in root as well as in crown development, and indicate that the decrease in the amount of these molecules and the fragmentation of the epithelial root sheath are interrelated.
N Obara; Y Suzuki; Y Nagai; M Takeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  44     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-19     Completed Date:  1999-08-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  415-21     Citation Subset:  D; IM    
Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Cadherins / analysis*
Dentinogenesis / physiology
Enamel Organ / ultrastructure
Fluorescein-5-isothiocyanate / diagnostic use
Fluorescent Antibody Technique, Indirect
Fluorescent Dyes / diagnostic use
Immunoglobulin G / diagnostic use
Odontogenesis / physiology*
Rhodamines / diagnostic use
Tooth Crown / ultrastructure
Tooth Germ / ultrastructure*
Tooth Root / ultrastructure*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Cadherins; 0/Fluorescent Dyes; 0/Immunoglobulin G; 0/Rhodamines; 3326-32-7/Fluorescein-5-isothiocyanate

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