| Immunoexpression of angiogenesis, nitric oxide synthase, and proliferation markers in gingival samples of patients with aggressive and chronic periodontitis. | |
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MedLine Citation:
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PMID: 20429651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In periodontal tissues, angiogenesis seems to be important for the maintenance of healthy tissues and in periodontal diseases. Angiogenesis is regulated through a complex interplay of molecular signals mediated by growth factors involving extracellular matrix remodeling, endothelial cell migration and proliferation, capillary differentiation and anastomosis. However, the influence of angiogenesis in the development, progression, and healing of periodontal lesions is currently under investigation. This immunohistochemical study evaluates the expression of vascular endothelial growth factor (VEGF), microvessel density (MVD), nitric oxide synthase (NOS) 1 and 3, and Ki-67 in gingival tissues of patients with aggressive and chronic periodontitis. METHODS: Twenty-seven human gingival biopsies were taken from patients with chronic periodontitis (n = 14 patients), generalized aggressive periodontitis (n = 6 patients), and healthy periodontia (n = 7 patients). The specimens were immunohistochemically stained for VEGF, MVD, NOS 1 and 3, and Ki-67. RESULTS: The levels of VEGF, MVD, NOS 1 and 3, and Ki-67 were found to be significantly different among groups (P >0.001). Patients with aggressive periodontitis had higher levels of these markers compared to those in patients with chronic periodontitis and healthy patients. CONCLUSIONS: The analysis demonstrates a higher expression of all immunologic markers particularly in subjects with aggressive periodontitis. In summary, the data from this pilot investigation suggests that VEGF is an important factor in the pathogenesis of the aggressive and chronic forms of periodontitis. |
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Authors:
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Luciano Artese; Adriano Piattelli; Luciana Aparecida de Gouveia Cardoso; Daniel S Ferrari; Tatiana Onuma; Marcelo Piccirilli; Marcelo Faveri; Vittoria Perrotti; Maciej Simion; Jamil Awad Shibli |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of periodontology Volume: 81 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 718-26 Citation Subset: D; IM |
Affiliation:
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Dental School, University of Chieti-Pescara, Chieti, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aggressive Periodontitis / pathology* Biological Markers / analysis Cell Proliferation Chronic Periodontitis / pathology* Endothelial Cells / pathology Endothelium, Vascular / pathology Epithelial Attachment / blood supply, pathology Epithelium / blood supply, pathology Factor VIII / analysis Female Gingiva / blood supply, pathology* Humans Immunohistochemistry Ki-67 Antigen / analysis Male Microvessels / pathology Middle Aged Neovascularization, Physiologic / physiology* Nitric Oxide Synthase / analysis* Nitric Oxide Synthase Type I / analysis Nitric Oxide Synthase Type III / analysis Periodontium / pathology Vascular Endothelial Growth Factor A / analysis Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Ki-67 Antigen; 0/Vascular Endothelial Growth Factor A; 9001-27-8/Factor VIII; EC 1.14.13.39/NOS1 protein, human; EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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