Document Detail


Immunodystrophism: evidence for a novel alloimmune hypothesis for recurrent pregnancy loss involving Th1-type immunity to trophoblast.
MedLine Citation:
PMID:  11355799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy loss is the most common complication of pregnancy. Recurrent pregnancy loss occurs in approximately 1% of pregnant women. Many immunologic theories have been proposed but have not withstood rigorous analysis. A novel alloimmune hypothesis involving T helper (Th) 1-type immunity to trophoblast is the latest theory proposed for recurrent pregnancy loss. The basic hypothesis is, in the decidua there are myriad of antigen presenting cells and other immune response cells. In response to trophoblast invasion, these cells may become activated. A by-product of this activation is the secretion by these cells of either a predominant Th1 or Th2 cytokine profile. In cases where a Th1 cytokine profile predominates, chiefly, interferon-gamma, tumor necrosis factor, or interleukin-12, these cytokines may directly or indirectly be detrimental to early placental cell differentiation and growth and toxic to embryo development. Further evidence for this novel hypothesis comes from recent findings of a genetic predisposition for a vigorous Th1 cytokine response in these women due to a polymorphism in the IL1B promoter region. Further studies are needed to substantiate definitive causative links between Th1-immunity to trophoblast and recurrent pregnancy loss. Clinical trials are also needed to determine the best therapy for this disorder.
Authors:
J A Hill; B C Choi
Related Documents :
14557459 - Possible angiogenic roles of insulin-like growth factor ii and its receptors in uterine...
8397809 - Murine trophoblast failure and spontaneous abortion.
18972319 - Prognostic subgroup distribution in diffuse large b-cell lymphoma of the upper aerodige...
2960609 - Alterations in immunological reactivity during pregnancy in mice determined in vitro by...
9047009 - Dual expression of prolactin-related protein in decidua and trophoblast tissues during ...
9935119 - A subset of cd56+ large granular lymphocytes in first-trimester human decidua are proli...
16710749 - Trizygotic quintuplet pregnancy following simultaneous embryo splitting in an oocyte do...
15124189 - Placental thickness in the first half of pregnancy.
6851559 - The zoapatle iv--toxicological and clinical studies.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  18     ISSN:  1526-8004     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2000  
Date Detail:
Created Date:  2001-05-17     Completed Date:  2001-09-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / immunology*
Antigen-Presenting Cells / immunology
Cytokines / physiology
Female
Humans
Isoantibodies / immunology*
Pregnancy
T-Lymphocytes, Helper-Inducer / immunology*
Trophoblasts / immunology*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Alloimmune causes of recurrent pregnancy loss.
Next Document:  Environmental toxins associated with recurrent pregnancy loss.