Document Detail

Immunocytotoxicity, cytogenotoxicity and genotoxicity of cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis.
MedLine Citation:
PMID:  25164019     Owner:  NLM     Status:  Publisher    
There is an increased use of Quantum Dot (QDs) in biological and biomedical applications, but little is known about their marine ecotoxicology. So, the aim of this study was to investigate the possible immunocytotoxic, cytogenotoxic and genotoxic effects of cadmium telluride QDs (CdTe QDs) on the marine mussel Mytilus galloprovincialis. Mussels were exposed to 10 μg L(-1) of CdTe QDs or to soluble Cd [Cd(NO3)2] for 14 days and Cd accumulation, immunocytotoxicity [hemocyte density, cell viability, lysosomal membrane stability (LMS), differential cell counts (DCC)], cytogenotoxicity (micronucleus test and nuclear abnormalities assay) and genotoxicity (comet assay) were analyzed. Results show that in vivo exposure to QDs, Cd is accumulated in mussel soft tissues and hemolymph and induce immunotoxic effects mediated by a decrease in LMS, changes in DCC, as well as genotoxicity (DNA damage). However, QDs do not induce significant changes in hemocytes density, cell viability and cytogenetic parameters in opposition to Cd(2+). Soluble Cd is the most cytotoxic and cytogenotoxic form on Mytilus hemocytes due to a higher accumulation of Cd in tissues. Results indicate that immunotoxicity and genotoxicity of CdTe QDs and Cd(2+) are mediated by different modes of action and show that Mytilus hemocytes are important targets for in vivo QDs toxicity.
Thiago Lopes Rocha; Tânia Gomes; Cátia Cardoso; Julie Letendre; José Paulo Pinheiro; Vânia Serrão Sousa; Margarida Ribau Teixeira; Maria João Bebianno
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-4
Journal Detail:
Title:  Marine environmental research     Volume:  101C     ISSN:  1879-0291     ISO Abbreviation:  Mar. Environ. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882895     Medline TA:  Mar Environ Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  29-37     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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