Document Detail


Immunocytochemical study of progesterone receptors in the human endometrium during the menstrual cycle.
MedLine Citation:
PMID:  3199799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Specific mouse monoclonal antibody (alpha PR6) against progesterone receptor was used with an avidin biotin complex technique to localize progesterone receptors in frozen sections of 26 normal cyclic human endometria. Progesterone receptor was detected in the nuclei of epithelial and stromal cells in both the functionalis and basalis layers. In the functionalis, the receptor content increased from the early to the late proliferative phase in both cell components. It remained high in the early secretory phase and decreased in the mid- and late secretory phases, comparatively more rapidly in the epithelium than in the stroma. In the latter, the predecidual cell nuclei were receptor-positive. The menstrual phase endometrium lacked receptors. The basalis was rich in progesterone receptors during the proliferative, early and midsecretory phases in both components and receptor-free during the late secretory and menstrual phases of the cycle. Myometrial smooth muscle cell nuclei contained progesterone receptors, whereas they were absent in endometrial and myometrial vessels. Overall, the epithelial progesterone receptor content seemed to correlate with the endometrial tissue levels of estradiol, possibly reflecting its estrogen sensitivity, whereas the stromal progesterone receptor content during the secretory phase at least, in part, may be constitutively synthetized.
Authors:
C Bergeron; A Ferenczy; D O Toft; W Schneider; G Shyamala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Laboratory investigation; a journal of technical methods and pathology     Volume:  59     ISSN:  0023-6837     ISO Abbreviation:  Lab. Invest.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376617     Medline TA:  Lab Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  862-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Endometrium / analysis*
Female
Frozen Sections
Humans
Immunoblotting
Immunohistochemistry
Menstrual Cycle*
Middle Aged
Myometrium / analysis
Receptors, Progesterone / analysis*
Chemical
Reg. No./Substance:
0/Receptors, Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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