Document Detail


Immunocytochemical study of pituitary oncocytic adenomas.
MedLine Citation:
PMID:  9224529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using immunocytochemistry we have analyzed 8 pituitary oncocytomas, 14 null cell adenomas, and 2 oncocytomas of the parotid gland (Warthin's tumor). The proportions of adenoma cells that are positive for mitochondrial protein (MP), cytochrome oxidase (COX), and manganese-superoxide dismutase (Mn-SOD) were significantly higher in pituitary oncocytomas than in null cell adenomas (MP P < 0.001, COX P < 0.001, Mn-SOD P < 0.05). In pituitary oncocytomas, MP-positive cells were distributed unevenly but in clusters or in islets admixed with some MP-negative cells, and corresponded to COX-positive cells. In contrast, almost all of the oxyphilic epithelial cells of Warthin's tumor were positive for MP, COX, and Mn-SOD. On the other hand, both pituitary tumors displayed similar findings with regard to the proportion of adenoma cells immunoreactive for copper/zinc-SOD and adenohypophysial hormones, the Ki-67 (MIB-1) proliferating cell index, and the mean number of argyrophilic nucleolar organizer regions. It was confirmed that immunocytochemical identification of MP and COX is useful for distinguishing pituitary oncocytomas from null cell adenomas. Although it remains to be determined whether oncocytomas originate from oncocytic changes of tumor cells or from neoplastic transformation of oncocytic cells, it appears that tumorigenesis of pituitary oncocytomas differs from that of Warthin's tumor.
Authors:
H Nishioka; H Ito; A Hirano; N Shibata; M Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  94     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-19     Completed Date:  1997-08-19     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Tokyo Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenolymphoma / chemistry,  pathology,  ultrastructure
Adenoma, Oxyphilic / chemistry,  pathology*,  ultrastructure
Adult
Aged
Aged, 80 and over
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mitochondria / chemistry,  enzymology,  ultrastructure
Neoplasm Proteins / analysis
Parotid Neoplasms / chemistry,  pathology,  ultrastructure
Pituitary Neoplasms / chemistry,  pathology*,  ultrastructure
Chemical
Reg. No./Substance:
0/Neoplasm Proteins

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