Document Detail

Immunocytochemical study of the action of cis-dichlorodiamino platinum on the human metaphase chromosome.
MedLine Citation:
PMID:  11596509     Owner:  NLM     Status:  MEDLINE    
The reaction of cis-dichlorodiamino platinum (cis-Pt) with the human metaphase chromosome was studied using both Giemsa staining and the action of anti-cis-Pt antibody. Two kinds of experiment were performed: (1) cis-Pt was placed in contact with cells in culture (in vivo tests), (2) cis-Pt was placed in contact with chromosomes fixed on slides (in vitro tests). In vivo, the presence of cis-Pt during phase G1 of the cell cycle is important for the reaction; in vitro, competition between cis-Pt and Giemsa for fixation on chromosomal DNA was shown to occur.
J Morin-Faure; M Marcollet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cell biology     Volume:  30     ISSN:  0171-9335     ISO Abbreviation:  Eur. J. Cell Biol.     Publication Date:  1983 May 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2001-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906240     Medline TA:  Eur J Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  316-9     Citation Subset:  IM    
Laboratoire d'Histologie-Embryologie-Cytogénétique, U.E.R. Médecine, Clermont-Ferrand/France.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Azure Stains / pharmacology
Cell Cycle
Cells, Cultured
Chromosomes / drug effects*
Cisplatin / pharmacology*
Cross-Linking Reagents / pharmacology*
Immunohistochemistry / methods*
Metaphase / drug effects*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Azure Stains; 0/Cross-Linking Reagents; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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