| Immunocytochemical localization and messenger ribonucleic acid concentrations for human placental lactogen in amnion, chorion, decidua, and placenta. | |
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MedLine Citation:
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PMID: 2187357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human placental lactogen is one of the major hormones secreted by the placental syncytiotrophoblast and detected in the maternal circulation. Other sources of this hormone in intrauterine tissues at term have been sought by means of immunohistochemistry and northern analysis. Avidin-biotin immunoperoxidase staining with a specific polyclonal antibody to human placental lactogen showed this hormone to be present in groups of cells at the interface between chorionic cytotrophoblast and decidua parietalis and in some cells of the basal plate in addition to the classic source, the syncytiotrophoblast. Hybridization of polyadenylic-(+)ribonucleic acid extracted from amnion, chorion, decidua parietalis, basal plate, and placental trophoblast with a radiolabeled 48 mer oligonucleotide and a 540 base pair complementary deoxyribonucleic acid probe to human placental lactogen showed the placental trophoblast to be the major source of human placental lactogen and the extravillous chorion and basal plate to be additional minor sources. |
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Authors:
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V Sakbun; S M Ali; Y A Lee; C S Jara; G D Bryant-Greenwood |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 162 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-06-15 Completed Date: 1990-06-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1310-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Anatomy and Reproductive Biology, University of Hawaii, Honolulu 96822. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amnion
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metabolism* Blotting, Northern Chorion / metabolism* DNA Probes Decidua / metabolism* Female Humans Immunoenzyme Techniques Oligonucleotide Probes Placenta / metabolism* Placental Lactogen / biosynthesis, genetics, metabolism* Pregnancy RNA, Messenger / metabolism* Trophoblasts / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM11796/GM/NIGMS NIH HHS; RR08125-14/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; 0/Oligonucleotide Probes; 0/RNA, Messenger; 9035-54-5/Placental Lactogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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