| Immunocytochemical localization of lymphatic and venous vessels in colonic polyps and adenomas. | |
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MedLine Citation:
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PMID: 17990106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Histopathological localization of lymphatic vessels has been hindered because of a lack of suitable immunocytochemical markers for lymphatic vessels. Using lymphatic vessels endothelial hyaluronan receptor-1 (LYVE-1) immunocytochemical staining, hyperplastic polyps, tubular adenomas to villous adenomas, were investigated for lymphatic vessels compared with immunostained blood vessels using factor-8. Four cases each of hyperplastic polyps, tubular adenomas to villous adenomas, were routinely fixed in formalin and embedded in paraffin and were immunostained using goat anti-LYVE-1 for lymphatic vessels and rabbit anti-factor-8 for blood vessels. In normal colon and hyperplastic polyps, slender lymphatic vessels were noted in muscularis mucosa, which spread into the base of colonic crypt, whereas round venous vessels, they extend into lamina propria. In tubular adenomas, small lymphatic and venous vessels were noted in broad fibrous stalks. In villous adenomas, smaller lymphatic and venous vessels were noted in fine intervillous stroma. In normal colon and hyperplastic polyps, slender, irregularly shaped lymphatic vessels were present in muscularis mucosa, spreading into the base of the colonic crypt. In tubular adenomas, small lymphatic and venous vessels were noted in fibrous stalks. In villous adenomas, smaller lymphatic and venous vessels were noted in intervillous stroma. There are no increased lymphatic and venous vessels in intermucosal stroma and stalks of adenomas compared with normal colon. |
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Authors:
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Tatsuo Tomita |
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Publication Detail:
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Type: Journal Article Date: 2007-11-09 |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 53 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-05-28 Completed Date: 2008-08-14 Revised Date: 2012-03-02 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1880-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Integrative Biosciences, Oregon Health and Science University, 611 SW Campus Drive, Portland, OR 97239-3097, USA. tomitat@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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blood supply* Aged Aged, 80 and over Colonic Neoplasms / blood supply* Colonic Polyps* Female Humans Immunohistochemistry / methods* Lymphatic Vessels* Male Middle Aged Veins* Vesicular Transport Proteins |
| Chemical | |
Reg. No./Substance:
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0/LYVE1 protein, human; 0/Vesicular Transport Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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