Document Detail

Immunocytochemical localization of calspectin (a non-erythroid spectrin-like protein) in thyroid glands of normal and TSH-treated rats.
MedLine Citation:
PMID:  3301749     Owner:  NLM     Status:  MEDLINE    
The localization of calspectin (fodrin, a non-erythroid spectrin-like protein), which is known to bind calmodulin and F-actin, was detected in the thyroid gland of normal and TSH-treated rats by means of light-microscopic immunocytochemistry. Calspectin was demonstrated in the cytoplasm of the follicle epithelial cells especially along the baso-lateral plasma membrane in normal rats. In TSH-treated animals, in addition to the baso-lateral plasma membrane region, the apical plasma membrane region of the follicle epithelial cells also showed positive reaction to the immunostaining. These results suggest that calspectin, in conjugation with calmodulin and actin, play a role in the secretory activities including reabsorption activity of colloid of the follicle epithelial cell.
K Ishimura; T Senda; K Kitajima; H Fujita; Y Fujio; K Sobue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histochemistry     Volume:  86     ISSN:  0301-5564     ISO Abbreviation:  Histochemistry     Publication Date:  1987  
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0411300     Medline TA:  Histochemistry     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  537-9     Citation Subset:  IM    
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MeSH Terms
Calmodulin-Binding Proteins / immunology,  metabolism*
Cell Membrane / metabolism
Fluorescent Antibody Technique
Rats, Inbred Strains
Thyroid Gland / drug effects,  metabolism*
Thyrotropin / pharmacology*
Reg. No./Substance:
0/Calmodulin-Binding Proteins; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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