| Immunocytochemical identification of human chorionic gonadotropin- and alpha-fetoprotein-producing cells of hepatoblastoma associated with precocious puberty. | |
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MedLine Citation:
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PMID: 6187119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A one-year-five-month-old boy with hepatoblastoma producing both human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) is presented. Histologically, the primary tumor was mainly composed of well differentiated hepatoblastoma cells, with minor areas of poorly differentiated cells. Immunoperoxidase staining of the tumor for hCG and AFP showed that a few well differentiated, fetal type cells and multinucleated giant cells were positive for hCG, and AFP was never stained in the same cells. In areas where cells were poorly differentiated, positive reactions for either hCG or AFP were not observed. Electron microscopic studies revealed focal aggregates of cytoplasmic cored vesicles in some tumor cells, similar to secretory granules. |
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Authors:
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A Nakagawara; K Ikeda; Y Hayashida; M Tsuneyoshi; M Enjoji; A Kawaoi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Virchows Archiv. A, Pathological anatomy and histopathology Volume: 398 ISSN: 0174-7398 ISO Abbreviation: Virchows Arch A Pathol Anat Histopathol Publication Date: 1982 |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302198 Medline TA: Virchows Arch A Pathol Anat Histopathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 45-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular
/
analysis*,
complications,
pathology,
surgery Chorionic Gonadotropin / analysis* Histocytochemistry Humans Immunoenzyme Techniques Infant Liver Neoplasms / analysis*, complications, pathology, surgery Male Postoperative Period Puberty, Precocious / etiology* alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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