Document Detail


Immunocytochemical identification of Rochalimaea henselae in bacillary (epithelioid) angiomatosis, parenchymal bacillary peliosis, and persistent fever with bacteremia.
MedLine Citation:
PMID:  1530106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the immunocytochemical identification of Rochalimaea henselae, a newly recognized fastidious, Gram-negative, Warthin-Starry-positive organism, as the common pathogen in bacillary angiomatosis (BA), bacillary peliosis (BP) of the liver and spleen, and persistent fever with bacteremia in immunocompromised patients. Immunogenic proteins of the R. henselae strain isolated from the blood of a febrile immunocompromised patient with BP of the liver were used to produce primary immune serum in rabbits. Using immunocytochemical procedures, the polyclonal antiserum reacted strongly not only with the immunizing strain of the bacteria, but also with other blood isolates of R. henselae (five cases) from both immunocompromised and immunocompetent patients and with the organisms present in the tissue lesions of cutaneous BA (five cases) and BP of the liver (two cases) and spleen (one case). The blood isolates and BA and BP tissue samples were obtained from widely separated geographic areas. The antiserum was weakly cross-reactive with cultures of Rochalimaea quintana, an organism closely related to R. henselae, but this reactivity was eliminated by specific adsorption. The antiserum did not cross-react with the Warthin-Starry-positive organisms associated with cat scratch disease (Afipia felis), syphilis (Treponema pallidum), Lyme disease (Borrelia burgdorferi) or chronic active gastritis (Helicobacter pylori). Likewise, the antiserum did not identify organisms in eight cases of Kaposi's sarcoma, a disorder of immunocompromised patients that is clinically similar to BA. Further studies are needed to determine the prevalence of this newly recognized organism as well as its possible involvement in other angioproliferative diseases.
Authors:
J A Reed; D J Brigati; S D Flynn; N S McNutt; K W Min; D F Welch; L N Slater
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  16     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-10-16     Completed Date:  1992-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  650-7     Citation Subset:  IM; X    
Affiliation:
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications
Adult
Aged
Angiomatosis, Bacillary / microbiology*
Antibodies, Bacterial / analysis
Bacteremia / microbiology*
Female
Fever / etiology
Gram-Negative Bacteria / immunology,  isolation & purification*
Gram-Negative Bacterial Infections / microbiology*
HIV Infections / complications
Humans
Immunohistochemistry
Male
Peliosis Hepatis / microbiology*
Purpura / microbiology*
Skin / microbiology
Splenic Diseases / microbiology*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial

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