Document Detail

Immunocytochemical examinations of biological traces on expanding bullets (QD-PEP).
MedLine Citation:
PMID:  18990519     Owner:  NLM     Status:  MEDLINE    
When a crime victim has been injured with several different objects, it is of central importance for the forensic investigation to be able to show which object caused which injury, especially if one of the injuries was lethal. In cases of bullet penetration wounds it is often not possible to find such evidence. However, immunocytochemical investigations can accurately match a victim's injury to a particular bullet path through the body. In cases where expanding bullets have been used and the heart or liver has been struck by a projectile, it can be shown that the cells remaining on the bullet stem from those particular organs. In this case the specific cytological evidence was established by means of marking heart- and liver-specific tissue proteins with appropriate antibodies (cardiac troponin I and HepPar 1) followed by disclosure with an appropriate chromogen. Thus, in principle, cells can be used as evidence after being extracted from the projectiles by either damp cotton-wool swabs or adhesive trace evidence tape. Because of the specificity of the used immunocytochemical antibodies, finding evidence of an antigen on a particular projectile proves that it was the object that injured the organs.
Frank Wehner; Nikolaus Rudolf Maria Moos; Heinz-Dieter Wehner; David Martin; Martin Manfred Schulz
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Publication Detail:
Type:  Journal Article     Date:  2008-11-05
Journal Detail:
Title:  Forensic science international     Volume:  182     ISSN:  1872-6283     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  IM    
Institut für Gerichtliche Medizin der Universität Tübingen, Nägelestrasse 5, D-72074 Tübingen, Germany.
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MeSH Terms
Antibodies / analysis
Antibodies, Monoclonal / immunology
Biological Markers
Forensic Ballistics
Forensic Pathology
Hepatocytes / immunology*
Liver / cytology*
Myocardium / cytology*
Sensitivity and Specificity
Staining and Labeling
Troponin I / immunology*
Wounds, Gunshot / pathology*
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Monoclonal; 0/Biological Markers; 0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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