| Immunocytochemical evidence for the presence of somatostatin-like immunoreactive nerves in human dental pulp. | |
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MedLine Citation:
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PMID: 1671397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Specific antiserum to somatostatin was used for the immunocytochemical detection of this neuropeptide in human dental pulp. Immunoreactive axon varicosities were observed in the radicular as well as coronal pulp. Fibers displaying somatostatin-like immunoreactivity were detectable within radicular nerve trunks and were found to be associated mainly with blood vessels. Nevertheless, positive fibers with no apparent relation to blood vessels were also observed. No pulp cell was found to be immunoreactive. Previous physiological studies demonstrated that somatostatin may function as a regulatory peptide in feline dental pulp via a pre-synaptic inhibition of substance P release from sensory nerve terminals. It is tempting to speculate that such a mechanism may also be effective in human teeth and may be of value in the regulation of pulpal blood flow and in situations when sensory nerve fibers are activated, e.g., during pulpal inflammation. |
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Authors:
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A Casasco; A Calligaro; M Casasco; D R Springall; J M Polak; C Marchetti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dental research Volume: 70 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-13 Completed Date: 1991-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 87-9 Citation Subset: D; IM |
Affiliation:
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Institute of Histology and Embryology, University of Pavia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Axons
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chemistry,
immunology Dental Pulp / blood supply, chemistry*, innervation* Fluorescent Antibody Technique Humans Immunohistochemistry Peptides / analysis* Somatostatin / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/somatostatin-like peptides; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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