Document Detail

Immunocytochemical evidence for alpha-melanocyte-stimulating hormone in the hypothalamus of the frog Rana esculenta.
MedLine Citation:
PMID:  3300993     Owner:  NLM     Status:  MEDLINE    
The distribution of immunoreactive alpha-melanocyte-stimulating hormone (alpha-MSH) within the brain of the frog, Rana esculenta, has been studied on adjacent serial sections using an indirect immunofluorescence technique. Immunoreactive cell bodies are found in the anterior part of the preoptic nucleus and in some ventral subependymal cerebrospinal fluid-contacting elements, and in the nucleus infundibularis ventralis. Numerous alpha-MSH-like immunoreactive fibers are present in the preoptic area, in the pars ventralis of the tuber cinereum, and in the outer layer of the median eminence. This staining pattern is completely eliminated after preabsorbing the antiserum with the corresponding antigen, but blocking tests with alpha-MSH-related peptides do not lead to any change in the immunoreaction. From these results it may be inferred that an alpha-MSH-like system is present in the hypothalamic neurosecretory area of R. esculenta, and is probably related to its hypophysiotropic functions. The results are compared to the distribution of alpha-MSH within the hypothalamus of reptiles and mammals.
M Vallarino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue research     Volume:  248     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  559-63     Citation Subset:  IM    
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MeSH Terms
Fluorescent Antibody Technique
Hypothalamus / cytology*
Melanocyte-Stimulating Hormones / analysis*
Neurons / cytology
Rana esculenta
Reg. No./Substance:
9002-79-3/Melanocyte-Stimulating Hormones

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