| Immunocytochemical detection of hMSH2 and hMLH1 expression in oral melanoma. | |
| | |
MedLine Citation:
|
PMID: 10810349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The DNA mismatch repair system (MMR) plays an important role in the maintenance of genomic stability. To date few studies have been performed on hMSH2 and hMLH1 expression and melanoma of the head and neck region. A study of two cases revealed no mutations of the mismatch repair genes hMSH2 and hMLH1. MATERIALS AND METHODS: To verify the possibility of implication of hMSH2 and hMLH1 alterations in melanocytic cancerogenesis, the authors examined the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in 9 paraffin-embedded oral melanoma. RESULTS: One case (11%) showed nuclear positivity for hMSH2, 3 cases (33%) showed cytoplasmic positivity, and five cases (55%) showed no staining in the tumoral cells, even if normal squamous epithelium available in this section showed a nuclear positivity. Four cases (44%) showed no hMLH1 staining in the tumoral cells, even if normal squamous epithelium available in this section showed a nuclear positivity. Two cases (22%) showed nuclear positivity, and three cases (33%) showed cytoplasmic positivity. CONCLUSIONS: The analysis of mismatch repair genes can be a new molecular diagnostic tools for the detection of patients at high risk of developing melanoma and other neoplasia, or metastasis and recurrences. |
| | |
Authors:
|
L Lo Muzio; P Nocini; M D Mignogna; G Pannone; S Staibano; M Procaccini; C Rubini; M Fioroni; S Fanali; A Piattelli |
Related Documents
:
|
22493579 - Omalizumab for chronic urticaria: a case series and overview of the literature. 7889669 - Agminate spitz naevi arising on hyperpigmented patches. 12962839 - Kaposi's visceral sarcoma in liver transplant recipients. 11314359 - Rhabdomyosarcoma in children: report of two cases. 18346589 - Synovial sarcoma: a case report. 18337649 - Vulvar melanoma: a report of 10 cases and review of the literature. 7097339 - Persisting recessus infundibuli and empty sella. case report. 12753689 - Hemodialysis catheter-associated endocarditis: clinical features, risks, and costs. 18094869 - Cerebellar abscess by gemella morbillorum in a patient with inter-atrial communication. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Anticancer research Volume: 20 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2000 Mar-Apr |
Date Detail:
|
Created Date: 2000-06-01 Completed Date: 2000-06-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
|
Languages: eng Pagination: 741-8 Citation Subset: IM |
Affiliation:
|
Department of Oral Medicine and Pathology, University of Naples Federico II, Faculty of Medicine and Surgery, Italy. lomuziol@tin.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptor Proteins, Signal Transducing Aged Aged, 80 and over Base Pair Mismatch Carrier Proteins Cell Nucleus / pathology Cytoplasm / pathology DNA Repair DNA-Binding Proteins* Female Gingival Neoplasms / pathology Humans Immunohistochemistry Lip Neoplasms / pathology Male Melanocytes / pathology Melanoma / pathology*, secondary Middle Aged Mouth Mucosa / pathology Mouth Neoplasms / pathology* MutS Homolog 2 Protein Neoplasm Metastasis Neoplasm Proteins / analysis* Nuclear Proteins Palatal Neoplasms / pathology Proto-Oncogene Proteins / analysis* |
| Chemical | |
Reg. No./Substance:
|
0/Adaptor Proteins, Signal Transducing; 0/Carrier Proteins; 0/DNA-Binding Proteins; 0/MLH1 protein, human; 0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; EC 3.6.1.3/MSH2 protein, human; EC 3.6.1.3/MutS Homolog 2 Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The study of gemcitabine in combination with other chemotherapeutic agents as an effective treatment...
Next Document: Human bladder carcinoma cells with an unusual pattern of in vitro growth: transition from nonprolife...