Document Detail


Immunocytochemical detection of hMSH2 and hMLH1 expression in oral melanoma.
MedLine Citation:
PMID:  10810349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The DNA mismatch repair system (MMR) plays an important role in the maintenance of genomic stability. To date few studies have been performed on hMSH2 and hMLH1 expression and melanoma of the head and neck region. A study of two cases revealed no mutations of the mismatch repair genes hMSH2 and hMLH1. MATERIALS AND METHODS: To verify the possibility of implication of hMSH2 and hMLH1 alterations in melanocytic cancerogenesis, the authors examined the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in 9 paraffin-embedded oral melanoma. RESULTS: One case (11%) showed nuclear positivity for hMSH2, 3 cases (33%) showed cytoplasmic positivity, and five cases (55%) showed no staining in the tumoral cells, even if normal squamous epithelium available in this section showed a nuclear positivity. Four cases (44%) showed no hMLH1 staining in the tumoral cells, even if normal squamous epithelium available in this section showed a nuclear positivity. Two cases (22%) showed nuclear positivity, and three cases (33%) showed cytoplasmic positivity. CONCLUSIONS: The analysis of mismatch repair genes can be a new molecular diagnostic tools for the detection of patients at high risk of developing melanoma and other neoplasia, or metastasis and recurrences.
Authors:
L Lo Muzio; P Nocini; M D Mignogna; G Pannone; S Staibano; M Procaccini; C Rubini; M Fioroni; S Fanali; A Piattelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  20     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-06-01     Completed Date:  2000-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  741-8     Citation Subset:  IM    
Affiliation:
Department of Oral Medicine and Pathology, University of Naples Federico II, Faculty of Medicine and Surgery, Italy. lomuziol@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing
Aged
Aged, 80 and over
Base Pair Mismatch
Carrier Proteins
Cell Nucleus / pathology
Cytoplasm / pathology
DNA Repair
DNA-Binding Proteins*
Female
Gingival Neoplasms / pathology
Humans
Immunohistochemistry
Lip Neoplasms / pathology
Male
Melanocytes / pathology
Melanoma / pathology*,  secondary
Middle Aged
Mouth Mucosa / pathology
Mouth Neoplasms / pathology*
MutS Homolog 2 Protein
Neoplasm Metastasis
Neoplasm Proteins / analysis*
Nuclear Proteins
Palatal Neoplasms / pathology
Proto-Oncogene Proteins / analysis*
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Carrier Proteins; 0/DNA-Binding Proteins; 0/MLH1 protein, human; 0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; EC 3.6.1.3/MSH2 protein, human; EC 3.6.1.3/MutS Homolog 2 Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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