Document Detail

Immunocytochemical demonstration of intermediate filaments in a granular cell ameloblastoma.
MedLine Citation:
PMID:  6199489     Owner:  NLM     Status:  MEDLINE    
The nature and location of intermediate filament proteins (IFP) may provide new insights into the origin and differentiation of neoplastic cells. An immunofluorescent study of these IFP in a case of a granular cell ameloblastoma revealed that all tumor cells contained the IFP keratin. Some granular cells, however, also contained the IFP vimentin, which is considered specific for mesenchymal tissues only. The implications of these observations are discussed. Study with monoclonal antibodies indicated the origin of the ameloblastoma from non-keratinized squamous epithelium. A comparison of the anti-keratin immunofluorescence pattern of the ameloblast-like cells in the present tumor with ameloblasts in the tooth germ revealed no similarities, indicating that despite some resemblance of the peripheral columnar cells to ameloblasts, these cells differ in other aspects.
P C de Wilde; P J Slootweg; H Müller; A Kant; O Moesker; P Vooijs; F C Ramaekers
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology     Volume:  13     ISSN:  0300-9777     ISO Abbreviation:  J. Oral Pathol.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-25     Completed Date:  1984-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342050     Medline TA:  J Oral Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  29-39     Citation Subset:  D; IM    
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MeSH Terms
Ameloblastoma / immunology,  metabolism*
Antibodies, Monoclonal / analysis
Fluorescent Antibody Technique
Intermediate Filament Proteins / immunology,  metabolism*
Keratins / immunology,  metabolism
Mandibular Neoplasms / immunology,  metabolism*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Intermediate Filament Proteins; 0/Vimentin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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