Document Detail

Immunocytochemical demonstration of intermediate filament proteins, S-100 protein and CEA in apocrine sweat glands and apocrine gland derived lesions of the dog.
MedLine Citation:
PMID:  2123589     Owner:  NLM     Status:  MEDLINE    
The presence of carcinoembryonic antigen (CEA), intermediate filament proteins and S-100 protein in normal and pathological canine apocrine sweat glands was investigated, using a standard immunoperoxidase technique. The normal apocrine sweat glands showed a constant immunoreactivity in all the cases studied. The cells of the acini and of the ducts only reacted with the antikeratin antibody. The myoepithelial cells reacted positively with the antisera antikeratin and anti protein S-100. Epithelial cells of apocrine cysts, sweat gland adenomas and sweat gland carcinomas showed the same immunoreaction than normal apocrine cells. Proliferating myoepithelial cells were also positive for vimentin. In two out of three adenocarcinomas a positive reaction with the anti CEA could be detected in the glandular cells. This can be due to the presence in glandular cells of CEA or of Nonspecific Crossreacting Antigen (NCA). These findings indicate that demonstration of keratin is a useful aid in the detection of apocrine gland derived lesions in the dog. Similarly, S-100 protein is a marker for myoepithelial cells. Further research is necessary to investigate the expression of CEA in canine tumours.
L Ferrer; R M Rabanal; D Fondevila; N Prats
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Veterinärmedizin. Reihe A     Volume:  37     ISSN:  0514-7158     ISO Abbreviation:  Zentralbl Veterinarmed A     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-14     Completed Date:  1991-01-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331323     Medline TA:  Zentralbl Veterinarmed A     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  569-76     Citation Subset:  IM    
Department of Pathology, Veterinary School, Universidad Autonoma de Barcelona, Spain.
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MeSH Terms
Apocrine Glands / chemistry*
Carcinoembryonic Antigen / analysis*
Dog Diseases / metabolism
Intermediate Filament Proteins / analysis*
S100 Proteins / analysis
Sweat Gland Diseases / metabolism,  veterinary
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Intermediate Filament Proteins; 0/S100 Proteins

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