Document Detail


Immunocytochemical demonstration of M(1) muscarinic acetylcholine receptors at the presynaptic and postsynaptic membranes of rat diaphragm endplates.
MedLine Citation:
PMID:  21469909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
M(1)-muscarinic acetylcholine (ACh) receptors (M(1)R) were directly demonstrated immunocytochemically in electronmicroscopic images of rat diaphragm neuromuscular junctions (NMJ). Specific electron-dense granules were located at presynaptic nerve ending membranes and in the sarcolemma in the depths of postsynaptic folds. This first visualization of M(1)R on both sides of the NMJ is in agreement with previous pharmacological data on the regulatory role of M(1)R in quantal and non-quantal ACh release.
Authors:
A I Malomouzh; S S Arkhipova; E E Nikolsky; F Vyskočil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  60     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-08-09     Revised Date:  2011-10-21    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  IM    
Affiliation:
Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diaphragm / innervation
Immunohistochemistry
Motor Endplate / metabolism*,  ultrastructure
Neuromuscular Junction / metabolism
Presynaptic Terminals / metabolism*,  ultrastructure
Rats
Receptors, Muscarinic / metabolism*
Synaptic Membranes / metabolism*
Synaptic Transmission / physiology*
Chemical
Reg. No./Substance:
0/Receptors, Muscarinic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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