Document Detail


Immunocompetent molecules and their response network in horseshoe crabs.
MedLine Citation:
PMID:  21528696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Horseshoe crab hemocyte selectively responds to bacterial lipopolysaccharides (LPS), which depends critically on the proteolytic activity of the LPS-responsive serine protease zymogen factor C. In response to stimulation by LPS, the hemocyte secretes several kinds of immunocompetent proteins. The coagulation cascade triggered by LPS or beta-1,3-D-glucans (BDG) results in the formation of coagulin fibrils that are subsequently stabilized by transglutaminase (TGase)-dependent cross-linking. Invading pathogens are recognized and agglutinated by lectins and then killed by antimicrobial peptides. Moreover, LPS-triggered hemocyte exocytosis is enhanced by a feedback mechanism in which the antimicrobial peptides serve as endogenous mediators. Factor C also acts as an LPS-sensitive complement C3 convertase. In addition, a sub-cuticular epidermis-derived protein forms a TGase-stabilized mesh at sites of injury. Horseshoe crabs have a sophisticated innate immune response network that coordinately effects pathogen recognition and killing, prophenoloxidase activation, complement activation and TGase-dependent wound healing.
Authors:
Shun-ichiro Kawabata
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  708     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-05-19     Revised Date:  2011-12-20    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  122-36     Citation Subset:  IM    
Affiliation:
Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan. skawascb@kyudai.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthropod Proteins
Enzyme Precursors / immunology*
Hemocytes / immunology
Horseshoe Crabs / immunology*
Immunity, Innate / immunology*
Lipopolysaccharides / immunology
Serine Endopeptidases / immunology*
Chemical
Reg. No./Substance:
0/Arthropod Proteins; 0/Enzyme Precursors; 0/Lipopolysaccharides; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.84/Limulus clotting factor C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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