| Immunochemotherapy for a systemic intracellular infection: accelerated response using interferon-gamma in visceral leishmaniasis. | |
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MedLine Citation:
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PMID: 7706829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine if cytokine immunotherapy accelerates the response to conventional treatment in visceral leishmaniasis (kala-azar), previously untreated Indian patients were given antimony for 30 days (n = 15) or antimony plus interferon-gamma (IFN-gamma; n = 16). After 10 days, 10 (63%) of 16 patients treated with antimony plus IFN-gamma versus 1 (7%) of 15 randomized to antimony alone were considered cured of parasites (P < .005). On day 20, 14 (93%) of 15 versus 6 (40%) of 15 patients, respectively, were apparent clinical cures (P < .006), and treatment was discontinued early in the 14 IFN-gamma treated responders. Day 30 apparent cure rates (100% vs. 73%) and 6-month ultimate cure responses (87% vs. 60%) were higher in IFN-gamma-treated patients but not statistically different from controls (P > .05). All 13 IFN-gamma-treated subjects who were cured (12 of whom received therapy for 20 days) have remained healthy with follow-up of 14-24 months (mean, 18.9). These results indicate that IFN-gamma successfully accelerates the parasitologic and clinical response to antimony treatment, an effect that should permit shortening the duration of conventional therapy in previously untreated kala-azar. |
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Authors:
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S Sundar; F Rosenkaimer; M L Lesser; H W Murray |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 171 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-05-05 Completed Date: 1995-05-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 992-6 Citation Subset: AIM; IM |
Affiliation:
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Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Antimony / therapeutic use* Child Child, Preschool Drug Therapy, Combination Female Humans Interferon-gamma, Recombinant / therapeutic use* Leishmania donovani / isolation & purification Leishmaniasis, Visceral / drug therapy*, parasitology Male Middle Aged Spleen / parasitology |
| Grant Support | |
ID/Acronym/Agency:
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AI-16963/AI/NIAID NIH HHS; RR-00047/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interferon-gamma, Recombinant; 7440-36-0/Antimony |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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