| Immunochemistry of food antigens. | |
MedLine Citation:
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PMID: 6391289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The complex mixture of molecules called food contains many types of molecules, some of which cause allergic or pseudo-allergic reactions in some humans. The identification of the antigenic molecules in the various foods and the type of allergic reaction they elicit is important for the satisfactory diagnosis in the individual patient and in the control of modified foods. The study of food antigens by crossed immunoelectrophoresis allows investigations of individual antigens without the interference of other antigens which are present simultaneously. We studied cow's milk electrophoresed into anti-bovine whey and anti-bovine casein. A number of precipitates are described, including albumin, alpha-lactalbumin, beta-lactoglobulin and immunoglobulin. The compositions of different infant milk formulae are compared with cow's milk heated under varying conditions. Albumin and immunoglobulins are the most labile components while beta-lactoglobulin is able to withstand even proteolysis by pepsin for some time. The antigenicity of these proteins in humans is shown by the presence of precipitating antibodies and specific IgE in human sera. Data from hen's egg white and wheat flour are reviewed in the same light. As an example of a reaction that is very difficult to differentiate from an immune reaction, the possible role of lectins is discussed. |
Authors:
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B Gjesing; H Løwenstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of allergy Volume: 53 ISSN: 0003-4738 ISO Abbreviation: Ann Allergy Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-01-18 Completed Date: 1985-01-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372346 Medline TA: Ann Allergy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 602-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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immunology Animals Antigens / immunology* Caseins / immunology Cattle Child Egg White / adverse effects Food* Food Hypersensitivity / immunology* Hot Temperature Humans Immunoelectrophoresis, Two-Dimensional Immunoglobulin E / immunology Immunoglobulins / immunology Infant Food Lactalbumin / immunology Lactoglobulins / immunology Lactose / immunology Lectins / immunology Mast Cells / immunology Milk / adverse effects Milk Proteins / immunology Plant Lectins Plant Proteins / immunology Secale cereale / adverse effects Triticum / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Antigens; 0/Caseins; 0/Immunoglobulins; 0/Lactoglobulins; 0/Lectins; 0/Milk Proteins; 0/Plant Lectins; 0/Plant Proteins; 37341-29-0/Immunoglobulin E; 63-42-3/Lactose; 9013-90-5/Lactalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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