Document Detail


Immunochemistry of factor VIII:C inhibitor antibodies.
MedLine Citation:
PMID:  1720928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Factor VIII:C (FVIII:C) inhibitors are pathologic circulating antibodies that reduce FVIII:C activity. They can arise either as alloantibodies in some congenital hemophiliacs, or as autoantibodies in nonhemophilic patients with acquired inhibitors. The reason for development of such antibodies is not known, but their basic biochemical and clinical characteristics have been reviewed extensively in the past several years. This article surveys recent immunochemical studies to characterize the FVIII:C molecule and antibodies against it. For instance, epitope (antigenic site) mapping investigations conducted to date suggest that binding sites for most inhibitory antibodies can be localized to limited regions of the FVIII:C molecule. Further progress in the understanding of immune responses against FVIII:C is likely to provide a sound basis for the design of new therapeutic approaches to patients suffering the sequelae of FVIII:C inhibitor antibodies.
Authors:
C A Fulcher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  91     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-01-16     Completed Date:  1992-01-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6S-8S     Citation Subset:  AIM; IM    
Affiliation:
Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, California 92037.
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MeSH Terms
Descriptor/Qualifier:
Autoantibodies / chemistry,  genetics,  immunology*
Epitopes / genetics
Factor VIII / chemistry,  genetics,  immunology*
Humans
Immunologic Techniques
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Epitopes; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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