Document Detail

Immunochemical studies of human kininogen.
MedLine Citation:
PMID:  6858754     Owner:  NLM     Status:  MEDLINE    
Antisera directed against the isolated heavy and light chains of high MW kininogen were used for immunochemical studies of high MW and low MW kininogens. The heavy chain region of high MW kininogen share identical immunologic determinants indicating similar structures. The light chain region of high MW kininogen is immunologically distinct from low MW kininogen and is therefore unique to high MW kininogen. Consequently the anti-heavy chain antibody could be used in radioimmunoassays to quantitate total kininogens antigens, whereas the anti-light chain antibody could be used as specific tool to quantitate high MW kininogen.
D M Kerbiriou; J H Griffin; M J Larrieu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  156     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-40     Citation Subset:  IM    
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MeSH Terms
Binding, Competitive
Blood Coagulation Disorders / blood
Chemical Phenomena
Immune Sera / pharmacology
Kininogens / analysis,  immunology*
Molecular Weight
Grant Support
Reg. No./Substance:
0/Immune Sera; 0/Kininogens

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