Document Detail


Immunochemical studies on the capsular polysaccharide of pneumococcal type IX.
MedLine Citation:
PMID:  4403878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. In addition to the previously identified components, d-glucose, N-acetyl-d-glucosamine and d-glucuronic acid, the immunologically specific capsular polysaccharide of pneumococcal type IX (polysaccharide S IX) is now found to contain mannosamine and galactosamine, probably as their N-acetyl derivatives. 2. Partial hydrolysis yields a complex mixture of oligosaccharides, several of which have been separated. 3. One of these is alpha-d-glucuronopyranosyl-(1-->3)-d-glucose. It is an inhibitor of the precipitation of antipneumococcal type IX serum by polysaccharide S IX. 4. Two others, d-glucuronopyranosyl-(1-->3)-d-glucosamine and d-glucuronopyranosyl-(1-->3)-d-galactosamine have been identified and a trisaccharide and pentasaccharide partially characterized.
Authors:
J D Higginbotham; A Das; M Heidelberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  126     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1972 Jan 
Date Detail:
Created Date:  1972-11-29     Completed Date:  1972-11-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromatography, Ion Exchange
Galactosamine / analysis
Hexosamines / analysis
Hydrolysis
Immune Sera
Mannose / analysis
Oligosaccharides / analysis
Polysaccharides, Bacterial / analysis*
Streptococcus pneumoniae / analysis*
Chemical
Reg. No./Substance:
0/Hexosamines; 0/Immune Sera; 0/Oligosaccharides; 0/Polysaccharides, Bacterial; 31103-86-3/Mannose; 7535-00-4/Galactosamine
Comments/Corrections

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