| IMMUNOCHEMICAL IDENTIFICATION OF PARATHYROID HORMONE IN NON-PARATHYROID NEOPLASMS ASSOCIATED WITH HYPERCALCEMIA. | |
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MedLine Citation:
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PMID: 14129717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Immunochemical cross-reactivity, but not identity, has been demonstrated between bovine parathyroid hormone and an antigen in biologically active extracts of human parathyroid tissue by quantitative C' fixation and C' fixation inhibition. 2. An antigen that fixes C' with rabbit antibody to bovine parathyroid hormone has been found in urea extracts of six human non-parathyroid neoplasms associated with a hypercalcemic syndrome mimicking primary hyperparathyroidism. Comparable extracts of control tissues and other tumors were serologically negative. 3. It is concluded that the tumor antigen is parathyroid hormone or a very closely related protein, and that its production by these neoplasms was the cause of the hypercalcemic syndrome in these six patients. |
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Authors:
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A H TASHJIAN; L LEVINE; P L MUNSON |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 119 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1964 Mar |
Date Detail:
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Created Date: 1964-07-01 Completed Date: 1996-12-01 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 467-84 Citation Subset: OM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergy and Immunology* Antibodies* Antigens* Biological Assay* Colonic Neoplasms* Hypercalcemia* Kidney Neoplasms* Lung Neoplasms* Pancreatic Neoplasms* Parathyroid Hormone* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens; 0/Parathyroid Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1964, by The Rockefeller Institute Received Day: 24 Month: 11 Year: 1963 Print publication date: Day: 29 Month: 2 Year: 1964 Volume: 119 Issue: 3 First Page: 467 Last Page: 484 ID: 2137886 PubMed Id: 14129717 |
| IMMUNOCHEMICAL IDENTIFICATION OF PARATHYROID HORMONE IN NON-PARATHYROID NEOPLASMS ASSOCIATED WITH HYPERCALCEMIA | |
| Armen H. Tashjian, Jr. | |
| Lawrence Levine | |
| Paul L. Munson | |
| From the Biological Research Laboratories, Harvard School of Dental Medicine, Department of Pharmacology, Harvard Medical School, Boston, and the Graduate Department of Biochemistry, Brandeis University, Waltham |
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