Document Detail

Immunochemical assessment of p16 and HPV L1 capsid protein in cervical squamous intraepithelial lesions.
MedLine Citation:
PMID:  21495457     Owner:  NLM     Status:  MEDLINE    
MATERIAL AND METHOD: The study involved 20 patients with cytological diagnosis of LSIL/CIN1 (low grade squamous intraepithelial lesion/cervical intraepithelial neoplasia) and HSIL (CIN2 and CIN3) (high grade squamous intraepithelial lesion), which underwent a subsequent cervical biopsy. The conventional smears were evaluated for the immunoexpression of L1HPV protein and the corresponding biopsies for the immunoexpression of p16.
RESULTS: The HPV L1 capsid protein was expressed in 46% of LSIL and 24% of HSIL. P16 was positive in 68% of LSIL, 84% of CIN2 and 100% of CIN3. The correlative analysis of p16 status and protein L1HPV expression can be very useful in the assessment of progression risk of cervical squamous intraepithelial lesions.
Raluca Balan; Simona Giuşcă; Irina Draga Căruntu; V Gheorghiţă; D Neacşu; Cornelia Amălinei
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i     Volume:  114     ISSN:  0048-7848     ISO Abbreviation:  Rev Med Chir Soc Med Nat Iasi     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-07-08     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0413735     Medline TA:  Rev Med Chir Soc Med Nat Iasi     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  1118-24     Citation Subset:  IM    
School of Medicine, ,Department of Morphology, Gr.T. Popa University of Medicine and Pharmacy Iaşi.
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MeSH Terms
Capsid Proteins / analysis*,  isolation & purification
Cell Transformation, Neoplastic
Cervical Intraepithelial Neoplasia / chemistry,  diagnosis*,  virology
Cyclin-Dependent Kinase Inhibitor p16 / analysis*
Cytodiagnosis / methods
Disease Progression
Immunohistochemistry / methods
Neoplasm Invasiveness
Oncogene Proteins, Viral / isolation & purification*
Papillomavirus Infections / diagnosis*,  metabolism
Predictive Value of Tests
Sensitivity and Specificity
Tumor Markers, Biological / analysis*
Uterine Cervical Neoplasms / chemistry,  diagnosis*,  virology
Vaginal Smears
Reg. No./Substance:
0/Capsid Proteins; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/HPV L1 protein, Human papillomavirus; 0/Oncogene Proteins, Viral; 0/Tumor Markers, Biological

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