Document Detail

Immunobullous diseases in Thai children: report of 24 cases.
MedLine Citation:
PMID:  14700167     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acquired immunobullous diseases in children are very rare and difficult to distinguish clinically. OBJECTIVE: To study the clinical manifestations, immunopathologic features, treatment and outcome of immunobullous diseases in Thai children. MATERIAL AND METHOD: The authors reviewed 24 cases of immunobullous diseases in children under 18 years at Queen Sirikit National Institute of Child Health from 1983 to 2000. Diagnosis of all cases was made by clinical presentations of chronic blistering diseases and confirmed by histopathology and immunofluorescent studies. RESULTS: There were 18 cases of chronic bullous diseases of childhood (CBDC), 4 cases of bullous pemphigoid (BP) and 2 cases of pemphigus vulgaris (PV). The mean age of onset of CBDC and BP were 4 years and 2 years respectively. There was an equal male to female ratio in both CBDC and BP. Both cases of pemphigus (neonate and 4 years old) were female. Most CBDC patients (18 cases) responded well to dapsone therapy although 2 cases had to be treated with prednisolone simultaneously. All cases with BP were treated successfully with prednisolone and dapsone. Neonatal pemphigus was treated symptomatically without steroid therapy. The second case of oral pemphigus was controlled with low dose prednisolone. CONCLUSION: Immunobullous diseases are very rare in children. All patients improved with corticosteroid and/or dapsone therapy.
Srisupalak Singalavanija; Wanida Limpongsanurak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  86 Suppl 3     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-12-31     Completed Date:  2004-02-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S681-8     Citation Subset:  IM    
Dermatology Division, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand.
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MeSH Terms
Age of Onset
Child, Preschool
Dapsone / therapeutic use
Infant, Newborn
Prednisolone / therapeutic use
Retrospective Studies
Skin Diseases, Vesiculobullous / drug therapy,  epidemiology*
Thailand / epidemiology
Reg. No./Substance:
50-24-8/Prednisolone; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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