| Immunobiotics and the probiotic evolution. | |
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MedLine Citation:
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PMID: 12900049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The term 'probiotic' was coined by the food industry to describe microbes beneficial to health. Scientific criticism based on poorly characterised isolates, soft clinical targets, and an absence of a mechanistic framework limited value of this concept. Current clinical and animal model studies support a role for certain 'probiotics', activating the common mucosal system through the stimulation of gut antigen-presenting cells to both promote protection and to switch regulatory mechanisms. It is concluded that a new term is required to identify bacteria that promote health through driving mucosal immune mechanisms, compared to those with strictly local effects. The term 'immunobiotics' is suggested as appropriate to fulfil this need. |
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Authors:
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Robert Clancy |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: 38 ISSN: 0928-8244 ISO Abbreviation: FEMS Immunol. Med. Microbiol. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-05 Completed Date: 2003-12-19 Revised Date: 2006-04-13 |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 9-12 Citation Subset: IM |
Affiliation:
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Discipline of Immunology and Microbiology, Royal Newcastle Hospital, Newcastle, NSW 2300, Australia. robert.clancy@newcastle.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diet Gastrointestinal Diseases / immunology, prevention & control* Humans Immune System / immunology*, microbiology Intestinal Mucosa / drug effects, immunology* Probiotics / therapeutic use* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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