Document Detail

Immunobiology of paediatric intracranial tumours. A preliminary report.
MedLine Citation:
PMID:  316267     Owner:  NLM     Status:  MEDLINE    
Preliminary findings in the evaluation of the immune response of children with primary neoplasms of the CNS, mainly medulloblastomas, are reported and discussed. A broad scheme for the monitoring of B- and T-cell-dependent immunity and of delayed hypersensitivity reactions in this type of patient is presented. The most important immunobiological findings are discussed. Special attention is given to the striking failure of the T-cell-dependent pool (currently identified by "active" RFC and blastigenesis tests) and to the remarkable decrease of hypersensitivity reactions (depressed skin-test response), both of which seem to be related to the degree of malignancy of the tumour. A very peculiar feature, i.e., the appearance of cells with natural cytotoxic activity, is dealt with in some detail. Our present knowledge concerning the immunobiology of primary CNS neoplasms is still very incomplete, but seems to suggest a possible role for immunotherapy in paediatric neurosurgery.
M Gerosa; G Amadori; C Semenzato; R Raumer; P Cisotto; A Pezzuto; G Gasparotto; A Carteri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  50     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  1979  
Date Detail:
Created Date:  1980-02-15     Completed Date:  1980-02-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / immunology*
Brain Neoplasms / immunology*
Brain Stem
Hypersensitivity, Delayed / immunology*
Leukocyte Count
Lymphocyte Activation
Medulloblastoma / immunology*
Rosette Formation
Skin Tests
T-Lymphocytes / immunology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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