| Immunobiology of face transplantation. | |
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MedLine Citation:
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PMID: 22337423 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT: Fourteen face transplants have been performed worldwide since the procedure was successfully introduced in 2005. Vascularized composite tissue allotransplantation may now be considered a viable option for the repair of complex craniofacial defects, for which the results of autologus reconstruction remain suboptimal. However, the benefits must be balanced against the risks inherent in major surgery and the adverse effects of lifelong immunosuppression. In this article, we review the current practice and areas of controversy in facial vascularized composite tissue allotransplantation with particular respect to the unique immunobiology of this procedure. We also describe promising recent advances in immunotherapy and tolerance induction strategies that may soon reach clinical application. |
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Authors:
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David A Leonard; Chad R Gordon; David H Sachs; Curtis L Cetrulo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of craniofacial surgery Volume: 23 ISSN: 1536-3732 ISO Abbreviation: J Craniofac Surg Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-02-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010410 Medline TA: J Craniofac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 268-71 Citation Subset: D |
Affiliation:
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From the *Transplantation Biology Research Center, and †Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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