Document Detail


Immunobiology of genital tract trauma: endocrine regulation of HIV acquisition in women following sexual assault or genital tract mutilation.
MedLine Citation:
PMID:  23034063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies on HIV acquisition and transmission in women exposed to sexual trauma throughout their life cycle are lacking, but some findings suggest that rates of HIV acquisition through coercive sex are significantly higher than that seen in consensual sex. Sexual trauma can also occur as a result of female genital mutilation, which makes sex extremely painful and can cause increased abrasions, lacerations, and inflammation, which enhances the risk of HIV acquisition. This review presents an overview of the immune system in the human female reproductive tract (FRT) from adolescence, through puberty to pregnancy and menopause. What is clear is that the foundation of information on immune protection in the FRT throughout the life cycle of women is extremely limited and at some stages such as adolescence and menopause are grossly lacking. Against this backdrop, forced or coercive sexual intercourse as well as genital mutilation further complicates our understanding of the biological risk factors that can result in transmission of HIV and other sexually transmitted infections.
Authors:
Mimi Ghosh; Marta Rodriguez-Garcia; Charles R Wira
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-04
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  69 Suppl 1     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-07     Completed Date:  2013-08-05     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  51-60     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Coitus*
Female
Genitalia, Female / injuries*
HIV Infections / epidemiology*,  transmission*
Humans
Male
Middle Aged
Pregnancy
Rape*
Unsafe Sex*
Grant Support
ID/Acronym/Agency:
AI071761/AI/NIAID NIH HHS; AI102837/AI/NIAID NIH HHS; AI51877/AI/NIAID NIH HHS; P01 AI051877/AI/NIAID NIH HHS; R01 AI071761/AI/NIAID NIH HHS; R01 AI102838/AI/NIAID NIH HHS; R03 AI102837/AI/NIAID NIH HHS
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