| Immunobiology of Dendritic Cells and the Influence of HIV Infection. | |
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MedLine Citation:
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PMID: 22975870 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recent progress in phenotyping of human dendritic cells (DCs) has allowed a closer alignment of the classification and functions of murine and human dendritic cell subsets. Marked differences in the functions of these human DC subsets and their response to HIV infection have become apparent, relevant to HIV pathogenesis and vaccine and microbicide development. Systems biology approaches to studying HIV uptake and infection of dendritic cells has revealed how markedly HIV subverts their functions, especially in relation to the trafficking pathways and viral transfer to T cells. Furthermore the interactions between DCs and other innate immune cells, NK cells, NKT cells and gamma delta T cells are now known to influence DC and T cell function and are also disturbed by HIV infection in vitro and in vivo. Such cellular interactions are potential targets for vaccine adjuvants and immunotherapy. |
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Authors:
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Anthony L Cunningham; Andrew Harman; Min Kim; Najla Nasr; Joey Lai |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 762 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1-44 Citation Subset: IM |
Affiliation:
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Westmead Millennium Institute, Westmead, 412, 2145, NSW, Australia, tony.cunningham@sydney.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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