Document Detail

Immunobiological activities of mould products: functional impairment of human monocytes exposed to aflatoxin B1.
MedLine Citation:
PMID:  8763624     Owner:  NLM     Status:  MEDLINE    
In order to elucidate the effects upon the human immune system of aflatoxin B1 produced by the food-contaminating mould Aspergillus flavus, phagocytosis, microbicidal activity, superoxide production and intrinsic antiviral activity were studied in monocytes exposed to aflatoxin B1 for different times at concentrations ranging from 0.1 to 1 pg/ml. Phagocytosis and microbicidal activity were significantly impaired (p < 0.05) by aflatoxin B1 at doses as low as 0.1 pg/ml. However, pretreatment of monocytes with aflatoxin B1 did not modify intrinsic antiviral activity or superoxide production. These results confirmed data obtained from animals fed with mycotoxin-contaminated foods. The potential danger to human health of exposure to mycotoxins demonstrates the necessity for careful microbiological control of food.
V Cusumano; F Rossano; R A Merendino; A Arena; G B Costa; G Mancuso; A Baroni; E Losi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Research in microbiology     Volume:  147     ISSN:  0923-2508     ISO Abbreviation:  Res. Microbiol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-04     Completed Date:  1996-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907468     Medline TA:  Res Microbiol     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  385-91     Citation Subset:  IM    
Institute of Microbiology, University of Messina, Italy.
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MeSH Terms
Aflatoxin B1 / pharmacology*
Candida albicans / drug effects*
Carcinogens / pharmacology*
Dose-Response Relationship, Drug
Monocytes / drug effects*,  metabolism,  microbiology
Phagocytosis / drug effects*
Superoxides / metabolism*
Reg. No./Substance:
0/Carcinogens; 11062-77-4/Superoxides; 1162-65-8/Aflatoxin B1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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