Document Detail


Immunoassay monitoring of polychlorinated biphenyls (PCBs) in the Great Lakes.
MedLine Citation:
PMID:  24234206     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Although polychlorinated biphenyls (PCBs) are no longer manufactured, they are still entering the environment. In some compartments of the environment, PCB concentrations are a serious concern. This is especially true in compartments which accumulate PCBs, and in food items consumed by humans and wildlife. Also, there are situations in which management decisions require rapid, sensitive, accurate measurements, which can be made in real time under field conditions. Methods to use an enzyme-linked immunosorbent assay (ELISA) for PCBs were developed and applied to sediments and fish muscle homogenates collected from the Great Lakes. The extraction methods developed can be applied in the field with non-hazardous solvents, in the absence of sophisticated laboratory equipment. The method detection limit for PCBs in dimethyl sulfoxide (DMSO) extracts of sediment was 0.9 mg/kg. For PCBs in isopropanol extracts of fish tissue, the method detection limit was 0.6 mg/kg. The resolution of the ELISA was 0.83 mg/kg at 1.1 mg/kg and 1.6 mg/kg at 1.7 mg/kg, for sediment and fish tissue, respectively.
Authors:
C A Richter; J B Drake; J P Giesy; R O Harrison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental science and pollution research international     Volume:  1     ISSN:  0944-1344     ISO Abbreviation:  Environ Sci Pollut Res Int     Publication Date:  1994 Mar 
Date Detail:
Created Date:  2013-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441769     Medline TA:  Environ Sci Pollut Res Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  -    
Affiliation:
Department of Fisheries and Wildlife, Pesticide Research Center, Institute for Environmental Toxicology, Michigan State University, 48824-1222, East Lansing, MI, USA.
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