| Immuno-neutralization of maternal plasma oestradiol stimulates fetal growth in rats. | |
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MedLine Citation:
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PMID: 3823604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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On day 12 of pregnancy, 7 rats were injected with 2 ml of an anti-oestradiol antiserum a quantity capable of binding 2.4 micrograms oestradiol. Seven further (control) rats were injected with an antiserum raised against human serum globulin. After sacrifice on day 21 of pregnancy, the fetuses from treated rats showed an increase in both placental weight (0.851 +/- 0.023 g, n = 98 vs 0.752 +/- 0.019 g, n = 97) and fetal weight (4.446 +/- 0.426 g, n = 98 vs 3.403 +/- 0.211 g, n = 97). There was no significant difference in protein, DNA and RNA contents between the fetuses from treated mothers and those from control mothers. This experiment confirms that oestrogens may play a role in fetal weight gain. |
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Authors:
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G S Spencer; K G Hallett; A Seddon; B A Morris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproduction, nutrition, development Volume: 26 ISSN: 0181-1916 ISO Abbreviation: Reprod Nutr Dev Publication Date: 1986 |
Date Detail:
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Created Date: 1987-04-01 Completed Date: 1987-04-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8005903 Medline TA: Reprod Nutr Dev Country: FRANCE |
Other Details:
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Languages: eng Pagination: 1289-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryonic and Fetal Development / drug effects* Estradiol / immunology* Estrogen Antagonists / immunology, pharmacology* Female Pregnancy Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Antagonists; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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