Document Detail

Immuno-neutralization of maternal plasma oestradiol stimulates fetal growth in rats.
MedLine Citation:
PMID:  3823604     Owner:  NLM     Status:  MEDLINE    
On day 12 of pregnancy, 7 rats were injected with 2 ml of an anti-oestradiol antiserum a quantity capable of binding 2.4 micrograms oestradiol. Seven further (control) rats were injected with an antiserum raised against human serum globulin. After sacrifice on day 21 of pregnancy, the fetuses from treated rats showed an increase in both placental weight (0.851 +/- 0.023 g, n = 98 vs 0.752 +/- 0.019 g, n = 97) and fetal weight (4.446 +/- 0.426 g, n = 98 vs 3.403 +/- 0.211 g, n = 97). There was no significant difference in protein, DNA and RNA contents between the fetuses from treated mothers and those from control mothers. This experiment confirms that oestrogens may play a role in fetal weight gain.
G S Spencer; K G Hallett; A Seddon; B A Morris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproduction, nutrition, development     Volume:  26     ISSN:  0181-1916     ISO Abbreviation:  Reprod Nutr Dev     Publication Date:  1986  
Date Detail:
Created Date:  1987-04-01     Completed Date:  1987-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8005903     Medline TA:  Reprod Nutr Dev     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  1289-93     Citation Subset:  IM    
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MeSH Terms
Embryonic and Fetal Development / drug effects*
Estradiol / immunology*
Estrogen Antagonists / immunology,  pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
0/Estrogen Antagonists; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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