| Immuno-localization of type-IV collagen in the blood-gas barrier and the epithelial-epithelial cell connections of the avian lung. | |
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MedLine Citation:
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PMID: 23193049 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The terminal respiratory units of the gas exchange tissue of the avian lung, the air capillaries (ACs) and the blood capillaries (BCs), are small and rigid: the basis of this mechanical feature has been highly contentious. Because the strength of the blood-gas barrier (BGB) of the mammalian lung has been attributed to the presence of type-IV collagen (T-IVc), localization of T-IVc in the basement membranes (BM) of the BGB and the epithelial-epithelial cell connections (E-ECCs) of the exchange tissue of the lung of the avian (chicken) lung was performed in order to determine whether it may likewise contribute to the strength of the BGB. T-IVc was localized in both the BM and the E-ECCs. As part of an integrated fibroskeletal scaffold on the lung, T-IVc may directly contribute to the strengths of the ACs and the BCs. |
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Authors:
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S A Jimoh; J N Maina |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology letters Volume: 9 ISSN: 1744-957X ISO Abbreviation: Biol. Lett. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2012-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101247722 Medline TA: Biol Lett Country: England |
Other Details:
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Languages: eng Pagination: 20120951 Citation Subset: IM |
Affiliation:
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School of Anatomical Sciences, University of the Witwatersrand, , Johannesburg, South Africa. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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