Document Detail

Immuno-localization of type-IV collagen in the blood-gas barrier and the epithelial-epithelial cell connections of the avian lung.
MedLine Citation:
PMID:  23193049     Owner:  NLM     Status:  MEDLINE    
The terminal respiratory units of the gas exchange tissue of the avian lung, the air capillaries (ACs) and the blood capillaries (BCs), are small and rigid: the basis of this mechanical feature has been highly contentious. Because the strength of the blood-gas barrier (BGB) of the mammalian lung has been attributed to the presence of type-IV collagen (T-IVc), localization of T-IVc in the basement membranes (BM) of the BGB and the epithelial-epithelial cell connections (E-ECCs) of the exchange tissue of the lung of the avian (chicken) lung was performed in order to determine whether it may likewise contribute to the strength of the BGB. T-IVc was localized in both the BM and the E-ECCs. As part of an integrated fibroskeletal scaffold on the lung, T-IVc may directly contribute to the strengths of the ACs and the BCs.
S A Jimoh; J N Maina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology letters     Volume:  9     ISSN:  1744-957X     ISO Abbreviation:  Biol. Lett.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-05-09     Revised Date:  2014-02-25    
Medline Journal Info:
Nlm Unique ID:  101247722     Medline TA:  Biol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  20120951     Citation Subset:  IM    
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MeSH Terms
Basement Membrane / cytology,  ultrastructure*
Blood-Air Barrier / cytology,  ultrastructure
Capillaries / anatomy & histology*
Chickens / anatomy & histology*
Collagen Type IV / analysis*
Epithelial Cells / cytology,  ultrastructure
Lung / blood supply,  ultrastructure*
Microscopy, Electron
Reg. No./Substance:
0/Collagen Type IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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