Document Detail


Immunizing Effects of Cocultures of H22 Hepatocarcinoma Cells and Cartilage Polysaccharide on Murine H22 Hepatocarcinoma.
MedLine Citation:
PMID:  21535505     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  Hepatocarcinoma is a malignant cancer, which is threatening human lives. In order to disclose the immunizing effects of the cells and cartilage polysaccharide (CHCP) on liver cancer, murine H22 hepatocarcinoma model was set up. The survival time, life span, and survival rate of the CHCP group were better than model group or other groups which was immunized with cartilage short-chain polysaccharide (CPS) only or H22 cell lysate only. A series of experiments were proceeded and the results confirmed that the humoral immunity and cellular immunity were strengthened. HE staining, TUNEL assay, and Alcian staining were used to research the mechanism of the tumor specific antigen production which may be related to the apoptosis of H22 hepatocarcinoma cells induced by CPS or some new polysaccharide compound emerged. The animal experiment testified the relationship between H22 hepatocarcinoma cell apoptosis induced by CPS and the effect of murine H22 hepatocarcinoma immunoprophylaxis. Our data demonstrated that the coculture of cartilage polysaccharide and cancer cells may serve as a novel source of antihepatocarcinoma agent that may play an important role in future liver cancer immunoprophylaxis.
Authors:
Xue Han; An-Jun Liu; Xi-Hua Zhao; Yan-Dong Li; Guo-Qiang Zheng; Guo-Rong Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  -     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2011-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  H265-H273     Citation Subset:  -    
Affiliation:
Authors Han, Liu, Zhao, Zheng, and Zhang are with Key Laboratory of Food Nutrition and Safety, Ministry of Education, Inst. of Food Engineering and Biotechnology, Tianjin Univ. of Science and Technology, Tianjin 300457, P.R. China. Author Han is also with College of Biological Science and Engineering, Hebei Univ. of Science and Technology, Shijiazhuang 050018, P.R. China. Author Li is with Key Laboratory of Zoonosis Research, Ministry of Education, Inst. of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin Univ., Changchun 130062, P.R. China. Direct inquiries to author Liu (E-mail: liuanjun666@yahoo.com.cn).
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