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Immunization of Mice with Plasmodium TCTP delays establishment of Plasmodium infection.
MedLine Citation:
PMID:  25376500     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Translationally Controlled Tumor Protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial vaccine trial, P. falciparum TCTP (PfTCTP) was expressed in S. cerevisiae and used to immunise BALB/c mice. Following challenge with P. yoelii YM, parasitemia was significantly reduced during the early stages of infection. In the second vaccine trial, the TCTP from P. yoelii and P. berghei was expressed in E. coli and used in several mouse malaria models. A significant reduction in parasitemia in the early stages of infection was observed in BALB/c mice challenged with P. yoelii YM. A significantly reduced parasitemia at each day leading up to a delayed and reduced peak parasitemia was also observed in BALB/c mice challenged with the non-lethal P.c. chabaudi AS. These results suggest that TCTP has an important role for parasite establishment and may be important for pathogenesis. This article is protected by copyright. All rights reserved.
Authors:
Kim J Taylor; Thi Thu Hao Van; Susan M MacDonald; Steven R Meshnick; Ross T Fernley; Ian G Macreadie; Peter M Smooker
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-5
Journal Detail:
Title:  Parasite immunology     Volume:  -     ISSN:  1365-3024     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-7     Completed Date:  -     Revised Date:  2014-11-8    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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