Document Detail


Immunity to experimental neosporosis in pregnant sheep.
MedLine Citation:
PMID:  11240899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neospora caninum is an important cause of fetal loss in cattle but has also infrequently been shown to cause disease in sheep and goats. Experimental infection of pregnant sheep with N. caninum causes clinical and pathological changes very similar to those of neosporosis in cattle. An experiment in sheep was undertaken to examine whether infection with N. caninum before pregnancy conferred immunity to subsequent challenge with the parasite during pregnancy. Primary inoculation of NC1 tachyzoites subcutaneously, either before or during pregnancy, caused a significant temperature response in ewes, while those given a secondary challenge at 90 days gestation (dg) did not show such a response. Primary infection of 12 ewes during pregnancy resulted in the loss of all fetuses while a further 12 ewes inoculated with NC1 tachyzoites before mating and subsequently challenged with the same dose at 90 dg produced nine live and seven dead lambs. There were no fetal deaths in ewes only infected with Neospora before mating although there was serological evidence of vertical transmission in four of their clinically normal offspring while Neospora DNA was detected in the cerebrospinal fluid of a fifth healthy lamb. Thus an experimental primary infection with N. caninum during pregnancy killed all the fetuses while inoculation before pregnancy did not cause any mortality but did provide a degree of protection against subsequent challenge with Neospora during pregnancy.
Authors:
D Buxton; S Wright; S W Maley; A G Rae; A Lundén; E A Innes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite immunology     Volume:  23     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-06-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Affiliation:
Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, UK. buxtd@mri.sari.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Antibodies, Protozoan / blood
Coccidiosis / blood,  immunology*,  parasitology
DNA, Protozoan / analysis
Disease Models, Animal
Female
Fetal Blood
Immunization / veterinary
Immunoglobulin G / blood
Immunoglobulin M / blood
Infectious Disease Transmission, Vertical
Neospora* / immunology,  isolation & purification
Placenta / parasitology,  pathology
Polymerase Chain Reaction
Pregnancy
Pregnancy Complications, Infectious / immunology*,  parasitology
Sheep
Time Factors
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/DNA, Protozoan; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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