Document Detail

Immunisation of the preterm baby.
MedLine Citation:
PMID:  8228295     Owner:  NLM     Status:  MEDLINE    
The study was designed to quantify the preterm baby's response to routine childhood immunisations. A total of 69 preterm babies were put into two groups according to their gestational age: less than 32 weeks and between 32 and 35 weeks. Within each group the babies were randomly placed into one of three schedules for immunisation with diphtheria, tetanus, pertussis and oral poliomyelitis vaccines at 3, 4 and 5 months; 3, 4, 5 and 18 months; and 3, 4 and 10 months. Antibodies were measured before immunisation, one month after the third vaccine dose and at age 19 months. Of these children, 30 had further antibody estimations when they were between 4 and 5 years of age. One month after the third immunisation and at 19 months of age all infants, independent of gestational age, had adequate immunity to the four infections. Children sampled before and after their pre-school booster, with few exceptions, showed persistence of protective antibody and an enhanced response to the booster dose respectively. No correction needs to be made for prematurity when initiating routine immunisation in premature infants.
S Conway; J James; A Balfour; R Smithells
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of infection     Volume:  27     ISSN:  0163-4453     ISO Abbreviation:  J. Infect.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-10     Completed Date:  1993-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
Department of Paediatrics, General Infirmary, Leeds, U.K.
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MeSH Terms
Age Factors
Diphtheria Toxoid / administration & dosage
Immunization Schedule
Immunization, Secondary
Infant, Newborn
Infant, Premature / immunology*
Pertussis Vaccine / administration & dosage
Poliovirus Vaccine, Oral / administration & dosage
Tetanus Toxoid / administration & dosage
Reg. No./Substance:
0/Diphtheria Toxoid; 0/Pertussis Vaccine; 0/Poliovirus Vaccine, Oral; 0/Tetanus Toxoid
Comment In:
J Infect. 1994 Mar;28(2):230-2   [PMID:  8035005 ]

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