Document Detail

Immunisation of adults during an outbreak of diphtheria.
MedLine Citation:
PMID:  6402176     Owner:  NLM     Status:  MEDLINE    
In an outbreak of infection due to Corynebacterium diphtheriae in a hospital for mentally subnormal adults sera from 211 members of staff were screened for diphtheria antitoxin titres. Of these, 79 (37%) required immunisation, and a low dose preparation (1 LfU of diphtheria and 10 LfU tetanus toxoids) was offered. Of the 64 subjects who accepted a single immunisation and were subsequently retested, seroconversion to diphtheria toxoid occurred in 45 (70%), the rate being highest in younger adults. Seroconversion to tetanus toxoid occurred in 59% of subjects. Local reactions to the single dose were reported by 29 (43%) subjects, and nine (13%) experienced moderately severe local reactions and systemic symptoms. We conclude that adults should not be vaccinated without previous screening for susceptibility to diphtheria; that neither previous immunisation nor age is reliable in predicting the need for vaccination; and that though a single booster dose of diphtheria toxoid is probably effective in adults under 45, two doses should be given to those in the older age group.
S R Palmer; A H Balfour; A E Jephcott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  286     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  624-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cross Infection / prevention & control*
Diphtheria / prevention & control*
Diphtheria Antitoxin / analysis
Diphtheria Toxoid / administration & dosage,  adverse effects
Disease Outbreaks / prevention & control*
Drug Administration Schedule
Hospitals, Special
Mental Retardation
Middle Aged
Tetanus Toxoid / administration & dosage
Reg. No./Substance:
0/Diphtheria Antitoxin; 0/Diphtheria Toxoid; 0/Tetanus Toxoid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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