| Immunisation of adults during an outbreak of diphtheria. | |
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MedLine Citation:
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PMID: 6402176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an outbreak of infection due to Corynebacterium diphtheriae in a hospital for mentally subnormal adults sera from 211 members of staff were screened for diphtheria antitoxin titres. Of these, 79 (37%) required immunisation, and a low dose preparation (1 LfU of diphtheria and 10 LfU tetanus toxoids) was offered. Of the 64 subjects who accepted a single immunisation and were subsequently retested, seroconversion to diphtheria toxoid occurred in 45 (70%), the rate being highest in younger adults. Seroconversion to tetanus toxoid occurred in 59% of subjects. Local reactions to the single dose were reported by 29 (43%) subjects, and nine (13%) experienced moderately severe local reactions and systemic symptoms. We conclude that adults should not be vaccinated without previous screening for susceptibility to diphtheria; that neither previous immunisation nor age is reliable in predicting the need for vaccination; and that though a single booster dose of diphtheria toxoid is probably effective in adults under 45, two doses should be given to those in the older age group. |
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Authors:
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S R Palmer; A H Balfour; A E Jephcott |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British medical journal (Clinical research ed.) Volume: 286 ISSN: 0267-0623 ISO Abbreviation: Br Med J (Clin Res Ed) Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8302911 Medline TA: Br Med J (Clin Res Ed) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 624-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross Infection / prevention & control* Diphtheria / prevention & control* Diphtheria Antitoxin / analysis Diphtheria Toxoid / administration & dosage, adverse effects Disease Outbreaks / prevention & control* Drug Administration Schedule Female Hospitals, Special Humans Immunization* Male Mental Retardation Middle Aged Tetanus Toxoid / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Diphtheria Antitoxin; 0/Diphtheria Toxoid; 0/Tetanus Toxoid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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