Document Detail

Immune thrombocytopenic purpura in patients with ulcerative colitis.
MedLine Citation:
PMID:  14564634     Owner:  NLM     Status:  MEDLINE    
Extraintestinal manifestations of ulcerative colitis (UC) are well known, but immunologically mediated hematological diseases are relatively rare. We describe two cases of immune thrombocytopenic purpura (ITP) associated with preexisting UC. Our patients had typical symptoms of UC, and endoscopy showed pancolitis. During treatment with 5-aminosalicylic acid and steroids, severe thrombocytopenia was noted. ITP was diagnosed based on a normal to high number of megakaryocytes in the bone marrow, positive autoantibody to platelet membrane antigen, and absence of splenomegaly. Medical treatment, including increased dosage of steroids, failed to control UC and ITP in both patients. In the first patient, the platelet count recovered after colectomy, while the second patient died of a cerebral hemorrhage. We stress that a diagnosis of ITP should be considered for thrombocytopenia in patients with UC, especially those showing extensive and significant colonic inflammation, and that colectomy of UC might resolve resistant ITP.
Yohei Mizuta; Hajime Isomoto; Yoshiko Kadokawa; Yuko Akazawa; Shunzen Chin; Yusei Kanazawa; Fuminao Takeshima; Katsuhisa Omagari; Kunihiko Murase; Terumitsu Sawai; Tohru Nakagoe; Ikuo Murata; Shigeru Kohno
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  38     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-17     Completed Date:  2004-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  884-90     Citation Subset:  IM    
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
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MeSH Terms
Colitis, Ulcerative / complications*
Middle Aged
Purpura, Thrombocytopenic, Idiopathic / etiology*

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