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Immune thrombocytopenic purpura in adults in the last 10 years: single-centre experience.
MedLine Citation:
PMID:  22952099     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
(Full text is available at http://www.manu.edu.mk/prilozi). Background: Immune thrombocytopenic purpura (ITP) is a benign disease with low morbidity and mortality and frequent remissions that occur spontaneously or in response to first-line treatment with steroids or splenectomy. Aim: The purpose of this study is to describe the clinical outcomes of 170 patients with ITP diagnosed and/or treated in our hospital between 2000 and 2010. Methods and results: The median age at diagnosis was 47 years. Forty three (25%) were asymptomatic, 65% had minor skin or mucosal bleeding and 10% had significant bleeding from the gastrointestinal or genitourinary system. The median platelet count at diagnosis was 13 X 109/L (range: 0-98 X 10exp(9)/L). Median follow-up of all patients was 13 months. Ninety-five patients had a follow-up longer than 12 months, with median 44 months (range 14-384). Corticosteroids were the initial treatment for 161/170 (95%) patients, 38 (22%) were splenectomized, 25 (14.7%) were treated with intravenous gamma globulins, while 9 did not received any specific treatment. A complete response to initial treatment (prednisone ± splenectomy) was achieved in 55/161 (34.2%), a partial response in 90 (55.9%) and no response in 16 (9.9%) patients. In the group of patients with follow-up longer than 1 year; 28 (29%) patients had refractory or unresponsive ITP with a median follow-up of 66 months. All patients with refractory ITP were treated with steroids, 11 were splenctomized, significantly more patients with refractory ITP 12 (43%) were treated with IVIG compared with other ITP patients (16%), p = 0.005. The median age of 38 splenectomized patients was 28 years and it is significantly different from the other patients (p < 0.001). There were no significant differences in other characteristics between splenctomized or refractory ITP and other patients at diagnosis. Conclusion: Our results were similar to results already reported in other similar studies. Key words: immune thrombocytopenic purpura, corticosteroids, splenectomy.
Authors:
M Pavkovic; S Trpkovska-Terzieva; T Sotirova; A Latifi; L Cevreska; A Stojanovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prilozi / Makedonska akademija na naukite i umetnostite, Oddelenie za biološki i medicinski nauki = Contributions / Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences     Volume:  33     ISSN:  0351-3254     ISO Abbreviation:  Prilozi     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-09-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189513     Medline TA:  Prilozi     Country:  Macedonia    
Other Details:
Languages:  eng     Pagination:  121-33     Citation Subset:  IM    
Affiliation:
University Clinic for Haematology, Medical Faculty, Skopje, R. Macedonia.
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