Document Detail

Immune system: maturation of myeloid cells.
MedLine Citation:
PMID:  19495705     Owner:  NLM     Status:  MEDLINE    
Human and animal cell lines are important laboratory tools that can be used for studying a variety of cell functions. Some cell lines are blocked at a certain step of maturation and can be used in order to study the mechanisms involved in cell maturation. Because such cell lines can be differentiated toward a more mature-like phenotype after the addition of agents, they can replace primary cells in large screening experiments preventing daily isolation. The human promyelocytic HL-60 leukemia cell line is an attractive model for studying the events which occur in myeloid cells. Interestingly, these cells can be differentiated toward monocytes, macrophages, or granulocytes as described in the present chapter.
Jamila Ennaciri; Denis Girard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  550     ISSN:  1064-3745     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-04     Completed Date:  2009-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-203     Citation Subset:  IM    
Laboratoire de recherche en inflammation et physiologie des granulocytes, Institut National de la Recherche Scientifique (INRS) - Institut Armand Frappier, Université du Québec, Laval, Canada.
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MeSH Terms
Bone Marrow Cells / cytology,  immunology*
Cell Differentiation
Eosinophils / cytology
Flow Cytometry
HL-60 Cells
Macrophages / cytology
Neutrophils / cytology

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