Document Detail


Immune system inflammation in cocaine dependent individuals: implications for medications development.
MedLine Citation:
PMID:  22389080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Cocaine dependence is a chronic stress state. Furthermore, both stress and substance abuse have robust and reciprocal effects on immune system cytokines, which are known to be powerful modulators of mood. We therefore examine basal and provoked changes in peripheral cytokines in cocaine dependent individuals to better understand their role in the negative reinforcing effects of cocaine.
METHODS: Twenty-eight (16 F/12 M) treatment-seeking cocaine dependent individuals and 27 (14 F/13 M) social drinkers were exposed to three 5-min guided imagery conditions (stress, drug cue, relaxing) presented randomly across consecutive days. Measures of salivary cortisol, tumor necrosis factor alpha (TNFα), interleukin-10 (IL-10), and interleukin-1 receptor antagonist (IL-1ra) were collected at baseline and various post-imagery time-points.
RESULTS: Cocaine abusers demonstrated decreased basal IL-10 compared with social drinkers. They also showed significant elevations in pro-inflammatory TNFα when exposed to stress compared with when they were exposed to relaxing imagery. This was not observed in the social drinkers. Conversely, social drinkers demonstrated increases in the anti-inflammatory markers, IL-10 and IL-1ra, following exposure to cue, which were not seen in the dependent individuals.
CONCLUSIONS: Cocaine dependent individuals demonstrate an elevated inflammatory state both at baseline and following exposure to the stress imagery condition. Cytokines may reflect potentially novel biomarkers in addicted populations for treatment development.
Authors:
Helen C Fox; Carrol D'Sa; Anne Kimmerling; Kristen M Siedlarz; Keri L Tuit; Raymond Stowe; Rajita Sinha
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human psychopharmacology     Volume:  27     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-06-26     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06519, USA. helen.fox@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / epidemiology
Biological Markers / metabolism
Cocaine-Related Disorders / complications*,  immunology
Cues
Female
Humans
Imagery (Psychotherapy) / methods
Inflammation / etiology*,  immunology
Inflammation Mediators / metabolism*
Male
Reinforcement (Psychology)
Saliva / chemistry
Stress, Psychological / etiology*,  immunology
Time Factors
Young Adult
Grant Support
ID/Acronym/Agency:
P50 DA016556/DA/NIDA NIH HHS; P50-DA16556/DA/NIDA NIH HHS; R01 AA013892/AA/NIAAA NIH HHS; R0I-AA13892/AA/NIAAA NIH HHS; UL1 RR024139/RR/NCRR NIH HHS; UL1 RR024139/RR/NCRR NIH HHS; UL1 TR000142/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators
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