| Immune surveillance of the maternal/fetal interface: controversies and implications. | |
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MedLine Citation:
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PMID: 20304670 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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How the fetal 'allograft' avoids rejection during pregnancy remains a major unresolved immunological paradox. Recent work has suggested that fetomaternal tolerance is in fact maintained by a number of redundant mechanisms, but their relative importance has remained poorly defined. In this paper, I discuss an emerging controversy regarding the ability of maternal T cells to mediate fetal rejection at a time when they appear to be ignorant of fetal and placental antigens. This paradox within a paradox highlights two major research directions in the field of reproductive immunology that, when ultimately reconciled, promise to give significant insight into mechanisms of impaired fertility and compromised fetal and maternal health. |
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Authors:
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Adrian Erlebacher |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-03-19 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 21 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-10-15 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 428-34 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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New York University School of Medicine, New York, NY, USA. Adrian.Erlebacher@nyumc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Immune Tolerance Immunologic Surveillance Male Maternal-Fetal Exchange / immunology* Mice Placenta / cytology, immunology* Pregnancy / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI062980-01A1/AI/NIAID NIH HHS; R01-AI062980/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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